Delayed Release
functional coating solutions
Targeted Release. Acid Protection. Controlled Delivery
Delayed-release coating, also called enteric coating, is a functional polymeric film applied to tablets, capsules, pellets, or granules. It prevents drug release in the stomach (acidic pH) and ensures dissolution in the intestine (alkaline pH > 5.5). This targeted drug delivery solution is ideal for acid-labile APIs, protecting them from gastric fluids and ensuring precise release at the desired intestinal site.
These coatings can be tailored to achieve modified release profiles such as sustained, controlled, or delayed release. This flexibility supports improved therapeutic performance, consistent bioavailability, and better patient compliance through reliable intestinal drug delivery.
Key Functions
What COAT ICON® CR Delivers:
- Protects acid-sensitive APIs (e.g., PPIs, enzymes, probiotics)
- Prevents gastric irritation caused by certain drugs
- Ensures drug release in the intestine (pH ≥ 5.5 to 7.0)
- Delays onset of action for time-specific delivery
- Acetaminophen ER tablets
- Gliclazide ER tablets
- Aceclofenac ER tablets
Versatile Applications
Ensuring Effective Release of Sensitive Bioactives
- Proton pump inhibitors (Omeprazole, Pantoprazole)
- Probiotics, enzymes, herbal extracts
- Acid-sensitive bioactives (e.g., ascorbic acid)
- NSAIDs or antibiotics that cause gastric irritation
| Brand Name | Coating System | Polymer | Recon % | Optimal Weight Gain |
|---|---|---|---|---|
|
COAT ICON ® EN-C |
Organic |
CAP |
5 % |
8-10 %
|
|
COAT ICON ® EN-K |
Aqueous |
Methacrylic acid
copolymer type C |
20% |
8-10%
|
|
COAT ICON ® EN-H |
Organic |
HPMC-P |
5 % |
8-10%
|
|
Hydro alcoholic |
10% |
8-10%
|
||
|
COAT ICON ® EN-A1 |
Aqueous |
Methacrylic acid
copolymer |
20 % |
8-10% |
|
Organic |
9% |
8-10%
|
||
|
Hydro alcoholic |
9% |
8-10% |
||
|
COAT ICON ® EN-1:1 |
Hydro alcoholic |
Methacrylic
Acid and
methacrylate 1:1 |
10% |
8-10%
|
|
COAT ICON ® EN-LS |
Hydro alcoholic |
Combination of
L100 & S100
|
8% |
8-10% |
Key Advantages
Robust pH-Dependent Release Profile
Ensures precise drug release only in the intestinal environment (pH > 5.5), protecting acid-sensitive APIs.
Customizable Release Timing & Site
Enables targeted delivery to specific regions of the intestine—duodenum, jejunum, or ileum—based on therapeutic need.
Film-Forming Polymers Ensure Coating Integrity
Provides a uniform, durable coating layer that maintains functionality during storage and transit.
Compatible with Multilayer Coating Systems
Seamlessly integrates with additional functional coatings such as moisture barriers or taste masking.
Compliance & Safety
• Meets international regulatory standards (USP, Ph. Eur.)• Designed with pharma-grade excipients only• Available in GMP-certified, validated formats